In this presentation, Dr Strober provides us with new data on TNF alpha inhibition in the treatment of hidradenitis suppurativa (HS). HS is sometimes referred to as acne inversa; however, Dr Strober feels it is a different disease based upon a lot of lines of evidence.Based on recent insights into the pathogenesis of this disease, TNF inhibition has found to be an effective treatment. Essentially, it’s phenomenological, because if you look at lesional skin, there is more TNF alpha as compared to peri-lesional as compared to control skin. This isn’t to say that TNF is the only relevant cytokine; in fact, it may be the first of many which will be targeted over the next decade. Just like in psoriasis, TNF will be the first cytokine studied for targeting in HS.Dermatology Treatment
TNF-a Inhibition and the Treatment of Hidradenitis Suppurativa – Maui Derm
Hidradenitis suppurativa and metabolic syndrome: a comparative cross-sectional study of 3207 patients, PUBMED Research, Research, Dermatology, 0
Journal: Br. J. Dermatol. 2015 Aug;173(2):464-70 Author(s): Shalom G, Freud T, Harman-Boehm I, Polishchuk I, Cohen AD BACKGROUND: Hidradenitis...
Hidradenitis suppurativa: haploinsufficiency of gamma-secretase components does not affect gamma-secretase enzyme activity in vitro, PUBMED Research, Research, 0
Journal: Br. J. Dermatol. 2016 Sep;175(3):632-5 Author(s): Pink AE, Dafou D, Desai N, Holmes O, Hobbs C, Smith CH,...
Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology, PUBMED Research, Research, Dermatology, 0
Journal: Exp. Dermatol. 2013 Mar;22(3):172-7 Author(s): Melnik BC, Plewig G Recent findings in familial hidradenitis suppurativa (HS) demonstrated loss-of-function...
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Journal: Cutis 1978 Mar;21(3):338-41 Author(s): Storino WD, Engel GH Hidradenitis suppurativa, hyperhidrosis, and Fox-Fordyce disease represent some of the...
Comparison of morphologic criteria for actinic keratosis and squamous cell carcinoma using in vivo multiphoton tomography, Research, 0
Comparison of morphologic criteria for actinic keratosis and squamous cell carcinoma using in vivo multiphoton tomography
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Association of liprin β‐1 with Kank proteins in melanoma
Hidradenitis suppurativa (HS) Non-Profit (501c3) 2017 Registration
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“I WILL NOT HIDE” Hidradenitis suppurativa (HS) Patient Stories Book Series
The “I WILL NOT HIDE” Hidradenitis Suppurativa book series is now available. These patient story volumes tell the stories of Hidradenitis Suppurativa (HS) patients in vivid and personal narrative. Told by HS patients themselves.
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