Pathogenesis and pharmacotherapy of Hidradenitis suppurativa

Hidradenitis suppurativa Research


Author(s): Nazary M, van der Zee HH, Prens EP, Folkerts G, Boer J

The focus of this review is to discuss the pathogenesis and the pharmacotherapy of Hidradenitis suppurativa (HS). HS is a distressing chronic skin disorder characterized by abscesses, boils, fistulas and scarring, generally affecting the groins, anogenital area and axillae. It is a common disease with an estimated prevalence of 1%. The etiology is unknown. HS was thought to be a disease of the apocrine sweat glands, but histological findings indicate that HS is a disease arising from the hair follicles. Several pathogenic factors seem important including genetic predisposition, smoking, obesity and an aberrant immune response to commensal flora. The management of HS is tremendously challenging because effective therapies are lacking. Nevertheless, HS has been treated with topical and systemic antibiotics, retinoids and immunosuppressive drugs such as anti-TNF-α biologics with partial success. In this review we will also discuss a potential new therapy for HS with the anti-psoriases agent acitretin.


Dermatology Journal and/or Publisher

Journal Name: European journal of pharmacology
Journal Abbreviation: Eur. J. Pharmacol.
Journal Date Published: 2011-11-18


National Center for Biotechnology Information

PMID: 21930119
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/21930119
Lasted Revision: 2011-11-18


Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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