Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa

Hidradenitis suppurativa Research


Author(s): Ring HC, Bay L, Kallenbach K, Miller IM, Prens E, Saunte DM, Bjarnsholt T, Jemec GB

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginous regions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesized that clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differences were found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthy controls. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.


Dermatology Journal and/or Publisher

Journal Name: Acta dermato-venereologica
Journal Abbreviation: Acta Derm. Venereol.
Journal Date Published: 2016-07-05


National Center for Biotechnology Information

PMID: 27377144
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/27377144
Lasted Revision: 2017-02-28


Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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