MicroRNAs: key components of immune regulation

pubmed-ncbi-logos

Journal: Adv. Exp. Med. Biol. 2011;780:15-26

Author(s): Gracias DT, Katsikis PD

The regulation of gene expression at the posttranscriptional level has revealed important control levels for genes important to the immune system. MicroRNAs (miRNAs) are small RNAs that regulate gene expression by inhibiting protein translation or by degrading the mRNA transcript. A single miRNA can potentially regulate the expression of multiple genes and the proteins encoded. MiRNA can influence molecular signaling pathways and regulate many biological processes including immune function. Although the role of miRNAs in development and oncogenesis has been well characterized, their role in the immune system has only begun to emerge. During the past few years, many miRNAs have been found to be important in the development, differentiation, survival, and function of B and T lymphocytes, dendritic cells, macrophages, and other immune cell types. We discuss here recent findings revealing important roles for miRNA in immunity and how miRNAs can regulate innate and adaptive immune responses.

Dermatology Journal and/or Publisher

Journal Name: Advances in experimental medicine and biology
Journal Abbreviation: Adv. Exp. Med. Biol.
Journal Volume: 780, Issue:
Journal Date Published: 2011-01-01

National Center for Biotechnology Information

PMI ID: 21842361
Article: Source Link
Created: 2011-08-15

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for “Hidradenitis suppurativa”

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