Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa

Hidradenitis suppurativa Research


Author(s): Thomi R, Kakeda M, Yawalkar N, Schlapbach C, Hunger RE

BACKGROUND: Hidradenitis suppurativa (HS) is a recalcitrant chronic skin disease with poorly understood immunopathogenic mechanisms. Previous studies reported that the interleukin-36 (IL-36) cytokines [IL-36α, IL-36β, IL-36γ and IL-36 receptor antagonists (IL-36RA)] are important players in the pathogenesis of psoriasis (PS).

OBJECTIVE: We aim to determine whether the IL-36 cytokines are upregulated in patients with HS. For this purpose, we analysed local expression and systemic levels of the IL-36 cytokines in patients with HS and compared the results to healthy donors and patients with PS.

METHODS: Skin biopsies from healthy donors and HS and PS patients were analysed for expression of the IL-36 cytokines by immunohistochemistry and semiquantitative real-time PCR. The enzyme-linked immunosorbent assay (ELISA) was used to measure systemic levels of the IL-36 cytokines in the serum of the three donor groups.

RESULTS: The agonists IL-36α, IL-36β and IL-36γ were found to be upregulated in HS both systemically and lesionally, while the IL-36RA was not differently regulated in comparison to healthy donors.

CONCLUSION: Our findings suggest that the agonistic IL-36 isoforms are upregulated in HS. The relevance of the enhanced production of IL-36 cytokines in HS pathogenesis remains to be determined.


Dermatology Journal and/or Publisher

Journal Name: Journal of the European Academy of Dermatology and Venereology : JEADV
Journal Abbreviation: J Eur Acad Dermatol Venereol
Journal Date Published:


National Center for Biotechnology Information

PMID: 28602023
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/28602023
Lasted Revision: 2018-03-01


Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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