Immunohistochemical study of cytokeratins in hidradenitis suppurativa (acne inversa)

Hidradenitis suppurativa Research

Author(s): Kurokawa I, Nishijima S, Kusumoto K, Senzaki H, Shikata N, Tsubura A

In 14 cases of hidradenitis suppurativa, cytokeratin (CK) expression was studied immunohistochemically, using six antikeratin antibodies against CK1, CK10, CK14, CK16, CK17 and CK19, respectively. The draining sinus tract epithelium of hidradenitis suppurativa lesions was divided into three components: infundibular-like keratinized epithelium (type A), non-infundibular keratinized epithelium (type B), and non-keratinized epithelium (type C). In type A samples, CK17 (which is found in normal infundibulum) was not detected, suggesting fragility of this epithelial type. Keratin expression in types B and C epithelia was similar to that observed in the outer root sheath in normal hair follicles. Our results suggest that the draining sinus epithelium may possess characteristics of fragility, undifferentiation and hyperproliferation, as shown with CK expression.

Dermatology Journal and/or Publisher

Journal Name: The Journal of international medical research
Journal Abbreviation: J. Int. Med. Res.
Journal Date Published: 2002-05-23

National Center for Biotechnology Information

PMID: 12025520
Article Source:
Lasted Revision: 2017-02-14

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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