IL-36 in hidradenitis suppurativa: Evidence for a distinctive pro-inflammatory role and a key factor in the development of an inflammatory loop

Hidradenitis suppurativa Research

Author(s): Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG

BACKGROUND: A possible regulatory involvement of the interleukin (IL)-36 family in inflammatory diseases has been suggested.

OBJECTIVES: To analyze the expression of IL-36α, β, γ, and the antagonistic cytokines IL-36Ra, IL-37, and IL38 in the skin of hidradenitis suppurativa (HS) patients.

METHODS: Skin samples from lesional and corresponding perilesional HS skin, and from healthy controls were included in this study and analyzed by quantitative real-time RT-PCR. To evaluate the PCR results of IL-36α, β, and γ, a subset of skin samples was studied by immunohistochemistry.

RESULTS: Expression levels of IL-36α, β, γ, and IL-36Ra were all significantly higher in lesional HS skin compared to healthy controls. IL-37 and IL-38 were significantly higher in perilesional HS skin compared to healthy controls and decreased in lesional HS skin.

LIMITATIONS: Descriptive study and small sample size.

CONCLUSIONS: Our results showed a possible involvement of IL-36 cytokines in the inflammatory network of HS and a dysbalance between the agonistic and antagonistic cytokines in HS skin. This article is protected by copyright. All rights reserved.

Dermatology Journal and/or Publisher

Journal Name: The British journal of dermatology
Journal Abbreviation: Br. J. Dermatol.
Journal Date Published: 2017-10-04

National Center for Biotechnology Information

PMID: 28975626
Article Source:
Lasted Revision: 2017-10-04

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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