Author(s): Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG
BACKGROUND: A possible regulatory involvement of the interleukin (IL)-36 family in inflammatory diseases has been suggested.
OBJECTIVES: To analyze the expression of IL-36α, β, γ, and the antagonistic cytokines IL-36Ra, IL-37, and IL38 in the skin of hidradenitis suppurativa (HS) patients.
METHODS: Skin samples from lesional and corresponding perilesional HS skin, and from healthy controls were included in this study and analyzed by quantitative real-time RT-PCR. To evaluate the PCR results of IL-36α, β, and γ, a subset of skin samples was studied by immunohistochemistry.
RESULTS: Expression levels of IL-36α, β, γ, and IL-36Ra were all significantly higher in lesional HS skin compared to healthy controls. IL-37 and IL-38 were significantly higher in perilesional HS skin compared to healthy controls and decreased in lesional HS skin.
LIMITATIONS: Descriptive study and small sample size.
CONCLUSIONS: Our results showed a possible involvement of IL-36 cytokines in the inflammatory network of HS and a dysbalance between the agonistic and antagonistic cytokines in HS skin. This article is protected by copyright. All rights reserved.
Dermatology Journal and/or Publisher
Journal Name: The British journal of dermatology
Journal Abbreviation: Br. J. Dermatol.
Journal Date Published: 2017-10-04
National Center for Biotechnology Information
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/28975626
Lasted Revision: 2017-10-04
Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).