Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?

pubmed-ncbi-logos

Journal: Rev Endocr Metab Disord 2016 Sep;17(3):335-341

Author(s): Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC

Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interactions between endocrinological and metabolic alterations in the development of HS. Taking into account the endocrine functions of the human skin, several studies investigated the effects of hormones and the behavior of the pilosebaceous unit in the skin of patients with HS. In this review we describe the current view on the hormonal dysregulation and metabolic syndrome and their role in HS.

Dermatology Journal and/or Publisher

Journal Name: Reviews in endocrine & metabolic disorders
Journal Abbreviation: Rev Endocr Metab Disord
Journal Volume: 17, Issue: 3
Journal Date Published: 2016-09-01

National Center for Biotechnology Information

PMI ID: 27294593
Article: Source Link
Created: 2016-06-13

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for “Hidradenitis suppurativa”

HSAWARENESS.ORG | Fighting for Hidradenitis suppurativa (HS), a.k.a Acne Inversa Patient and Doctor Awareness ©2017 hidradenitissuppurativaawareness.org  All Rights Reserved. Your use of this website constitutes explicit agreement to our Terms of Use and Privacy Policies. This website does not provide medical advice, diagnosis or treatment.

Translate »

Log in with your credentials

Forgot your details?