Author(s): Karagiannidis I, Nikolakis G, Sabat R, Zouboulis CC
Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interactions between endocrinological and metabolic alterations in the development of HS. Taking into account the endocrine functions of the human skin, several studies investigated the effects of hormones and the behavior of the pilosebaceous unit in the skin of patients with HS. In this review we describe the current view on the hormonal dysregulation and metabolic syndrome and their role in HS.
Dermatology Journal and/or Publisher
Journal Name: Reviews in endocrine & metabolic disorders
Journal Abbreviation: Rev Endocr Metab Disord
Journal Date Published: 2016-06-13
National Center for Biotechnology Information
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/27294593
Lasted Revision: 2017-11-16
Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).