Hidradenitis suppurativa: the role of immune dysregulation

Hidradenitis suppurativa Research

Author(s): Kelly G, Sweeney CM, Tobin AM, Kirby B

Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory disease of follicular occlusion characterized by boils, sinus tracts, fistulae, and scarring. It has a significant underestimated morbidity. Antimicrobial, immunosuppressive, anti-androgenic, and surgical approaches have been used with varying results. Knowledge of the pathogenesis of HS is fragmented, and treatment choices have hitherto been empiric without an exact understanding of the scientific basis for their use. Tumor necrosis factor-α inhibitors have shown promise in the treatment of HS in recent years, and the concept of HS as an immunological condition has come to the fore. The focus of this review is to discuss the immunological abnormalities underpinning HS as elucidated to date.

Dermatology Journal and/or Publisher

Journal Name: International journal of dermatology
Journal Abbreviation: Int. J. Dermatol.
Journal Date Published: 2014-09-15

National Center for Biotechnology Information

PMID: 24961484
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/24961484
Lasted Revision: 2014-09-15

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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