Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis

Hidradenitis suppurativa Research


Author(s): Shlyankevich J, Chen AJ, Kim GE, Kimball AB

BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving intertriginous skin. Previous epidemiologic studies have been limited by small sample size.

OBJECTIVE: We sought to describe the prevalence and comorbidities of HS in a large patient care database.

METHODS: In this retrospective case-control study, we chart-validated all patients within a hospital database who received at least 1 billing code for HS between 1980 and 2013. Verified cases were matched with controls based on age, gender, and race. Prevalences of a priori selected comorbidities were compared between HS and control groups.

RESULTS: A total of 2292 patients at Massachusetts General Hospital received at least 1 code for HS. A total of 1776 cases had a validated diagnosis of HS, yielding a prevalence of 0.08%. In unadjusted analysis, all comorbidities were diagnosed significantly more in HS compared with control including (in rank order of likelihood): smoking, arthropathies, dyslipidemia, polycystic ovarian syndrome, psychiatric disorders, obesity, drug dependence, hypertension, diabetes, thyroid disease, alcohol dependence, and lymphoma (all P < .01).

LIMITATIONS: Control subjects were not validated for absence of HS and comorbidity validation was not performed for either group.

CONCLUSIONS: Our results highlights the high comorbidity burden of patients with HS compared with matched control subjects.


Dermatology Journal and/or Publisher

Journal Name: Journal of the American Academy of Dermatology
Journal Abbreviation: J. Am. Acad. Dermatol.
Journal Date Published: 2014-12-03


National Center for Biotechnology Information

PMID: 25440440
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/25440440
Lasted Revision: 2014-12-03


Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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