Adalimumab is an antibody that binds to TNF-alpha and interferes with its interaction with cell surface receptors. This product is marketed as Humira for the treatment of rheumatoid arthritis and Crohn’s disease.According to information submitted to the FDA, no adverse effects were noted in the offspring of monkeys treated with up to 100 mg/kg each week. This dose is at least 266 times the recommended human dose based on plasma concentrations.When a comparable antibody to mouse TNF alpha was administered to pregnant mice, there were no adverse effects on fetal survival or morphologic development (8). There were no adverse effects on immune function in the offspring except an inconsistent decrease in splenic cell expansion in females but not males (9). This observation may not be clinically important.Dermatology HUMIRA Pregnancy Treatment
Adalimumab During Pregnancy: Side Effects and Risks
HS Patient Stories
HS BOOK SERIES: “I WILL NOT HIDE” Hidradenitis suppurativa (HS)
Our series of book releases for #HSAWARENESS tell the stories of Hidradenitis Suppurativa (HS) patients in vivid and personal narrative. Told by the patients themselves.
“The support structure of the FPSUs is defective. Under the influence of endogenous reproductive hormones, exogenous hormones, androgens and their precursors in dairy products, and other dietary factors, the follicular unit is plugged and distended by retained keratin.”
— Margesson LJ, Danby FW