Active Hidradenitis Suppurativa lesions are associated with elevated Interferon-Gamma (IFN-γ) in wound exudate

A study by The George Washington University Ideas to Health laboratory indicates that the pro-inflammatory cytokine Interferon-gamma (IFN-γ) was significantly elevated in wound fluid exudate from HS patients. This finding lends support to the hypothesis that immune mechanisms play a role in the pathogenesis of HS and suggests that IFN-γ may play a crucial role as a molecular driver in HS disease activity. Future studies in the Ideas to Health Laboratory are focused on identifying biomarkers of disease activity in HS and investigating proinflammatory pathways that might help identify treatment options for this challenging disease.

“The immune system related defects in disease HS are not well understood and mechanisms driving disease activity are not known. This study not only confirms that cytokine profiles can be reliably measured on HS lesion effluent, but also suggests that IFN- γ likely contributes to the local inflammatory response in HS and may be crucial molecular driver of tissue injury in HS.”

Read The Full Source: Active Hidradenitis Suppurativa lesions are associated with elevated Interferon-Gamma (IFN-γ) in wound exudate | The Department of Medicine | The GW School of Medicine & Health Sciences

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