A clinical-pathological review of hidradenitis suppurativa: using immunohistochemistry one disease becomes two

Hidradenitis suppurativa Research

Author(s): Fismen S, Ingvarsson G, Moseng D, Nathalie Dufour D, Jørgensen L

We report the results of a re-examination of a series of 57 biopsies from 50 patients with the clinical diagnosis of hidradenitis suppurativa, submitted to the Department of Pathology at the University Hospital of Northern Norway, Tromsø, Norway. The biopsy material came from hospitals and physicians all over northern Norway in the years 2000-2007. All tissue material was resectioned and stained with the immunohistochemical reagent, cytokeratin (AE1/AE3/PKC26), and that made it possible to divide the material into two different disease categories: (1) 36 biopsies from 30 cases had tissue inflammation after rupture of keratin-rich epidermal cysts, which we call ‘horny cell inflammation’, followed by extensive cutaneous thrombi and infarcts, and (2) 21 biopsies from 20 cases had ‘apocrinitis’ defined here as an inflammatory destruction of apocrine skin glands, and partly of close eccrine glands. The two disease populations differed: the patients with a diagnosis of horny cell inflammation were younger and mainly women; those with a diagnosis of apocrinitis, as defined here, were older, men and women equally represented.

Dermatology Journal and/or Publisher

Journal Name: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
Journal Abbreviation: APMIS
Journal Date Published: 2012-05-15

National Center for Biotechnology Information

PMID: 22583355
Article Source: http://www.ncbi.nlm.nih.gov/pubmed/22583355
Lasted Revision: 2012-05-15

Abstract Source: National Center for Biotechnology Information, U.S. National Library of Medicine Abstract Query for Hidradenitis suppurativa (HS).


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